The Centers for Chemical Innovation (CCI) Program supports research centers focused on major, long-term fundamental chemical research challenges. CCIs that address these challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest. CCIs are agile structures that can respond rapidly to emerging opportunities and make full use of cyberinfrastructure to enhance collaborations. CCIs may partner with researchers from industry, government laboratories and international organizations. CCIs integrate research, innovation, education, and public outreach and include a plan to broaden participation of underrepresented groups.